Biohacking Bible - A Neuropharmacology Encyclopedia
All donations go towards the project.
---------------------------------------
In this e-book, I go over the substances that I think would be of most help to the hypodopaminergic phenotype of neuropsychiatric disorders (specifically anhedonia, treatment-resistant depression/anxiety, PSSD, DPDR and ADHD). A lot of pharmacological concepts are explained in sufficient detail.
Poor focus, depression and demotivation are often attributed to low dopamine and norepinephrine but low acetylcholine activity can also contribute sometimes. Acetylcholine is needed to maintain sustained attention and lack of acetylcholine due to low dietary choline can contribute to ADHD symptoms so make sure you eat enough choline-rich food like eggs, or supplement with CDP-choline/alpha-GPC. MAOIs increase concentrations of both dopamine and norepinephrine which is why they are highly regarded.
One of the main reasons behind hypodopaminergic symptoms such as anhedonia, social withdrawal, short attention span and sexual dysfunction is supersensitivity to serotonin or excessive serotonergic signaling. Serotonin acts as a counterbalance to dopamine in the brain for the most part (it’s brain region specific; cortical 5-HT2A increases dopamine release to the NAc; while hypothalamic 5-HT1A increases dopamine, β-endorphin, oxytocin there), so one of the best ways to go around this is to block specific serotonin receptors.
---------------------------------------
NOTE: none of this is medical advice. These are mainly my notes I’ve written after years of research. Some of the stuff mentioned in this guide are experimental and are marked as such.
It is NOT advisable to dabble with nootropics until you first adopt a healthy lifestyle first by getting your gut, immune system, blood levels, hormones in the best shape possible, and adopt a healthy diet (including drinking filtered rather than unfiltered water). This is mostly intended for the treatment-resistant type although some of the advice here can work for healthy people who want a bit of a boost. You just have to know what you are doing.
Remember to also get thyroid and blood panels done. Ideally test for all vitamins, minerals and hormones but if you can’t get your doctor to refer you for those tests, then get lab tests done yourself at a Spectracell lab or order an Idealabs kit (easiest and cheapest method).
You can also stack hepatoprotectors like black seed oil, NAC, TUDCA, Na-R-ALA/R-ALA, curcumin (with bioperine ideally), schisandra and/or milk thistle to reduce burden on the liver and protect from any hepatotoxic chemicals (including ones in your food). Safety note - never take TUDCA before alcohol as the combo is very toxic to the liver; and never take NAC after alcohol as the combo is, once again, toxic.
---------------------------------------
This ebook is constantly updated so feel free to check it every once in a while. And feel free to use the comment feature if you want to give feedback.
You can read it for free here. I do 1-on-1 consultations on Discord as well. I also host a GPT bot trained on this data and more. Instead of Gumroad, you can also pay using crypto or PayPal. None of this is medical advice; these are merely just pharmacology notes.